Pain and Inflammation Article

A Balanced Approach for Cannabidiol Use in Chronic Pain

Source: 
https://www.ncbi.nlm.nih.gov

Link: 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204604/

Article Summary:
In this mini-review, the focus is on cannabidiol (CBD) as a potential treatment for chronic pain, amid its growing popularity and regulatory challenges. CBD, a major non-psychoactive component of cannabis, has garnered interest for its analgesic properties, particularly in cases where conventional treatments fail or cause adverse effects. Studies have shown varied efficacy of CBD in alleviating chronic pain associated with conditions like multiple sclerosis, fibromyalgia, and neuropathy. However, the effectiveness of CBD appears to be context-dependent, influenced by factors such as the type of pain and individual responses. Mechanistic studies suggest CBD’s modulation of serotonin and other pathways involved in pain perception, contributing to its therapeutic potential.  Despite promising outcomes, the widespread availability of unregulated CBD products poses significant risks, including inaccurate labeling, contamination with harmful substances, and the potential for teratogenic effects, particularly concerning in pregnant women. Regulatory measures and enhanced education are urgently needed to ensure safe and effective use of CBD for chronic pain management, while rigorous research continues to explore its full therapeutic potential and associated risks.

Article Abstract:
Cannabidiol (CBD), the major non-psychoactive constituent of Cannabis sativa L., has gained traction as a potential treatment for intractable chronic pain in many conditions. Clinical evidence suggests that CBD provides therapeutic benefit in certain forms of epilepsy and imparts analgesia in certain conditions, and improves quality of life. CBD continues to be Schedule I or V on the list of controlled substances of the Drug Enforcement Agency of the United States. However, preparations labeled CBD are available publicly in stores and on the streets. However, use of CBD does not always resolve pain. CBD purchased freely entails the risk of adulteration by potentially hazardous chemicals. As well, CBD use by pregnant women is rising and poses a major health-hazard for future generations. In this mini-review, we present balanced and unbiased pre-clinical and clinical findings for the beneficial effects of CBD treatment on chronic pain and its deleterious effects on prenatal development.