MCAS Article

Article Summary:
Histamine is a biogenic amine that plays crucial roles in the body, including regulating wakefulness, digestion, tissue growth, and the immune response. When produced in excess, it can lead to histamine intolerance (HIT), a condition characterized by an inability to process histamine properly, resulting in symptoms like digestive issues, skin reactions, respiratory problems, and neurological disturbances. Diagnosis of HIT often involves detailed patient history, food diaries, and elimination diets, while treatment focuses on reducing high-histamine foods and supporting enzymatic breakdown through supplements like diaminoxidase (DAO) and probiotics. CBD (cannabidiol) has emerged as a potential aid for HIT due to its anti-inflammatory and antihistamine properties, which may help alleviate symptoms such as stress, pain, and allergic reactions. While initial studies suggest CBD’s efficacy in modulating histamine release and reducing allergic reactions, further research is needed to fully understand its impact on histamine intolerance.